Desensitisation protocols and duration

Desensitisation protocols

All desensitisation protocols are tailored to the patient's specific case and involved 2 successive phases:

 
The first phase, referred to as the "initial treatment"phase, has the purpose of stepping up the treatment's strength. Starting at a very low dose of the allergen involved, the allergist increase the dose of the product administered over the course of the first few weeks of treatment until the highest well-tolerated dose is reached. Depending on the route of administration (subcutaneous injection or sublingual administration) being used and the individual's sensitivity, this initial phase may last anywhere from 11 days to 14 weeks, or even one day.

The second phase, referred to as the "maintenance phase", can then begin. The maximum dose tolerated by the patient at the end of the initial phase is then given at regular intervals (depending on the route of administration and the individual's sensitivity) for a period ranging from 3 to 5 years or several pollen seasons.

 

 

The duration

How long a desensitisation protocol takes depends on the patient. In the same way that both the composition and dosage of the allergen solution is tailored to the individual, the duration of both the initial and the maintenance phase are determined by the individual's sensitivity and response.

On average, for perennial allergies:

Route of administration

Duration of the initial phase

Duration of the maintenance phase

Subcutaneous injection

12 to 14 weeks

 

3 to 5 years

 

Sublingual administration

11 days

On average, for seasonal allergies:


Route of administration

Duration of the initial phase

Duration of the maintenance phase

Subcutaneous injection

12 to 14 weeks

 

3 to 5 successive seasons

Sublingual administration

11 days for pre-seasonal treatment
1 day with rapid escalation of doses with medical monitoring for seasonal treatment

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